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indicated that the number of Purkinje cells in the vermis of the cerebellum was 15 standard deviations below the mean and approximately 8 standard deviations below the mean bilaterally in the cerebral hemispheres of the individuals with autism compared with controls

J Membr Biol 89:18 Lu SC, Ge JL, Kuhlenkamp J, Kaplowitz N (1992) Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat

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doi: 10.1002/art.41812 84 ZhangYMaoXLiWChenWWangXMaZet al

Studies have shown that c-MYC , a multifaceted transcriptional factor, upregulates glutamine importers and GLS1 expression and that p53, a tumor-suppressor gene/protein, upregulates GLS2 expression [46,47,48]